Wilshere has not played a single minute this season after sustaining an injury on his leg at the start of the campaign.
Cup holders Arsenal kick off the fifth round clashes with the visit of Hull and will hope to be in the mix come Sunday's sixth round draw.
Arsene Wenger is currently the longest-serving manager in the English top-flight and is in his 20th year in charge of Arsenal.
Arsene Wenger will manage his 100th game in the FA Cup against Hull City.
John Terry suffered a hamstring injury during Chelsea's 5-1 win over Newcastle United earlier in February.
Danny Welbeck made his first Arsenal appearance in over 10 months during the 2-1 win over Leicester City on 14 February.
Nick Powell wants to complete the season with Hull City before moving back to Manchester.
Watford face Leeds United in the fifth round FA Cup clash on Saturday. Find out how to follow the match live in the UK.
Arsenal are facing Hull City in the FA Cup for the third consecutive time.
Joe Ledley, Bakary Sako and Dwight Gayle could also feature, but James McArthur and Jason Puncheon remain out.
De Gea in a race against time to be fit for Premier League trip to Arsenal.
City boss claims he has just 13 senior outfield players fit and available for FA Cup fifth-round tie.
Gunners chief is attempt to win his side a third consecutive cup.
Adebayor returns to White Hart Lane this weekend as Tottenham host Crystal Palace in the FA Cup fifth round.
The 25-year-old forward made a dramatic return to first-team action against Leicester City.
New Zealand striker out of action since 26 January after recurring hamstring issue.
Head of medical and sports science Stijn Vandenbroucke has provided a fitness update ahead of fifth-round tie.
The 21-year-old defender has been one the sidelines nursing a hamstring injury of late.
Cech has played a key role in helping Arsenal mount a title challenge this campaign.
Koscielny will not be risked for the clash against Hull with the manager saving him for Barcelona's visit.
The 28-year-old midfielder is expecting an aggressive encounter against FC Midtjylland.
Wayne Rooney wants the Red Devils to concentrate on winning the Europa League.