Mauricio Pochettino's claimed sixth straight away win with 4-0 success at the Terriers.
Zouma, 22, joined Stoke on a season-long loan from Chelsea in July.
Reds have only won one of their last six matches in all competitions.
Giroud scored his 100th goal for Arsenal against Borisov.
Lukaku, 24, has scored 10 goals in nine games for United this season.
Wilshere has already made two starts this season.
The Gunners will also be without Francis Coquelin for the game.
Rafael Benitez admits facing the Reds will be special after six years with the Merseysiders.
Centre-back pair remain doubtful for Premier League clash with foot and hamstring injuries respectively.
Ruben Loftus-Cheek, James Tomkins and Wilfired Zaha all out of trip to Old Trafford.
Former Spurs star was forced off during 3-1 Champions League victory over Borussia Dortmund.
Blues host Premier League leaders following a midweek 2-1 victory over Atletico Madrid.
Speculation suggests that Frenchman could be sidelined until after the November international break.
Jurgen Klopp says both players are making progress but are unavailable this weekend.
Guardiola confirms that striker suffered a broken rib during road accident in Amsterdam.
Spain boss has left both out of of his 25-man squad for upcoming games against Albania and Israel.
Football ace was in Amsterdam to attend singer's concert.
CEO pledges that Gunners will continue plan to reinvest all available revenue in the club's playing resources.
Tottenham Hotspur star will miss upcoming World Cup qualifier against Slovenia.
England face Slovenia and Lithuania next week in their two remaining World Cup qualifiers.
The Toffees drew 2-2 with Apollon Limassol at home after conceding a late equaliser.
Midfielder wanted to boost World Cup chances but was seemingly subject to a lack of offers.
Palmeiras centre-back broke his foot during a Copa Libertadores clash on 10 August.
Arsenal beat BATE Borisov 4-2 in the Europa League on Thursday (28 September).
Discriminatory chanting has continued to be heard at Premier League grounds this season.
Ancelotti was sacked after Bayern fell to a 3-0 defeat against Paris Saint-Germain in the Champions League.
Reports suggest that Argentine striker suffered a fractured rib in road accident in Amsterdam on Thursday night.
Morata has seven goals in seven games in all competitions since moving to Chelsea.
Anthony Martial limped off during United's 4-1 win over CSKA Moscow.
Ozil is in the final nine months of his contract at Arsenal and is yet to agree an extension.