United manager Jose Mourinho has approved Rooney's exit from the club, according to reports.
Arsenal lost 4-0 on their last visit to the St Mary's.
Both players may have played his last game for the club against Brentford on Saturday.
The Blues boss made nine changes with a game against Liverpool looming midweek.
Mohamed Salah was involved in Egypt's goals in the 2017 African Cup of Nations.
DR Congo and Ghana face each other in the 2017 African Cup of Nations clash on 29 January.
Real Madrid looking to bounce back after their Copa del Rey exit in midweek.
Sanchez has 18 months left on his contract at Arsenal.
Tottenham had to play 20 minutes with 10 men after Trippier went off.
Barcelona looking to stretch winning run to six games across all competitions.
Arsenal did not induct Ozil, Coquelin and Ramsey in the squad against Southampton.
The 21-year-old has signed a three-and-a-half year deal with the Championship side.
The Reds have now lost three games in a row in the last seven days.
Saints are looking to knock Arsenal out of a second cup this season.
A late Son strike crushes the Chairboys.
Craig Gordon will replace Asmir Begovic at Chelsea.
Holders Manchester United will face Wigan in the fourth round FA Cup clash.
Arsenal are currently second in the Premier League, 8 points behind Chelsea.
Kick-off: 12:30pm
Manchester City are currently fifth in the Premier League.
Tottenham host Wycombe for the first time in any competitive fixture.
Chelsea have only one loss since the turn of the year.
Martial last featured in United's draw to Liverpool at Old Trafford on 15 January.
Xhaka is banned for four matches after picking up his second straight red of the season against Burnley.
Ghana international was stretchered off during Africa Cup of Nations game against Uganda.
The 19-year-old returned to action after 15-month injury spell in FA Cup clash against Plymouth Argyle.
Croatian international revealed the Blues tried to sign him when he was still in Switzerland.
Warren Joyce returns to Old Trafford after eight years as coach of the reserves.
The French boss also charged £25,000 for incidents of improper conduct and misconduct against Burnley.
Antonio Conte wants to find a replacement for Bosnian before letting him leave for Bournemouth.