Mourinho's side capitulated to Antonio Conte's team at Stamford Bridge.
Jack Wilshere is on a season-long loan at Bournemouth with fitness being the main objective.
Antonio Conte's Chelsea handed United their biggest defeat in the Premier League since 2011.
Boss said that beating Jose Mourinho's side was especially important following the defeats to Liverpool and Arsenal.
Ings made his only first-team appearance this season during Liverpool's win over Derby County.
Iniesta, 32, is set to miss Barcelona's next seven fixtures.
Sissoko elbowed Harry Arter in the final stages of Tottenham's draw against Bournemouth.
Former Villarreal defender was replaced by Marcos Rojo after suffering a suspected knee ligament injury.
Mourinho reported to have been angered by Conte's celebrations during the 4-0 win at Stamford Bridge.
Jose Mourinho suffers a humiliating return to Stamford Bridge as his side are thoroughly outclassed.
Wilshere is on a season-long loan at AFC Bournemouth.
Anfield icon looks set to depart Major League Soccer when his current contract expires next month.
Rooney, 30, has lost his place in the United team after a series of poor performances.
Arsenal's 6-game winning streak ended after the Gunners drew their game against Middlesbrough on 22 October.
Rooney last started in the Premier League during Manchester United's defeat to Watford.
Manchester City have not won a match in their last three games played in all competitions.
Chelsea and Manchester United face each other in the Premier League clash on 23 October.
Iniesta left the field in tears after he was tackled by Enzo Perez.
Mourinho was sacked by the Blues in December 2015, despite winning the Premier League that year.
Philippe Coutinho and Sadio Mane on target as Jurgen Klopp's side extend their unbeaten home run to 17 games.
The Gunners were well below their best against Middlesbrough in North London.
The teenager is considered to be among the brightest prospects at United.
Giggs served as a coach during David Moyes' troubled spell at the club.
The Premier League-winning boss adopted a cautious approach against Liverpool at Anfield.
The striker was substituted in Liverpool's goalless draw against their Premier League rivals.
Spurs maintain their unbeaten top-flight run with a hard-fought goalless draw on the south coast.
Scholes retired from football in 2013 after a trophy-laden spell at Old Trafford.
Wilshere last played the full 90 minutes against Manchester City in September 2014.
Arsene Wenger has completed 20 years in charge of Arsenal.
Forlan spent two seasons at Manchester United where he won the title once.