N'Golo Kante has not featured for Chelsea since the last international break and has missed their last six matches played in all competitions.
N'Golo Kante reportedly signalled to the media after Tuesday's Champions League loss to Roma that he had a "50-50" chance of playing against Manchester United.
Belgian urges his side to rebound against United after suffering a heavy defeat in Rome in the Champions League.
Matic's arrival at Old Trafford raised eyebrows in the summer, and Neville does not think Chelsea adequately replaced the Serbian.
Chelsea have managed only three wins in the last seven matches played in all competitions, which include Premier League defeats against Manchester City and Crystal Palace.
Antonio Conte explained Chelsea midfielder N'Golo Kante did not feel at 100% to play against Roma, with the club choosing not to risk him.
Giroud was close to joining Everton in the summer transfer window but eventually decided to remain at Arsenal.
Chelsea travel to the Italian capital looking to consolidate their place as Group C leaders after surrendering a lead at Stamford Bridge last time out.
Reports suggest that Chelsea are prepared to offer Cesc Fabregas a new contract amid interest from former manager and current Manchester Untied boss Jose Mourinho.
Moses has not been part of the Chelsea setup after picking up a hamstring injury in the 2-1 defeat by Crystal Palace at Selhurst Park earlier this month.
Belgium international Nainggolan, 29, signed a new four-year contract at Roma in July amid interest from Blues boss Antonio Conte.
Chelsea striker Alvaro Morata has moved to clarify comments that he cannot see himself living in London for very long due to too much stress.
AS Roma will assess Kostas Manolas and Gregoire Defrel ahead of Tuesday's Champions League visit of Chelsea, although Patrik Shick has been ruled out.
Peres suffered the injury during Roma's 1-0 victory over Bologna on the weekend, with tests confirming the severity of the tear on Monday (30 October).
N'Golo Kante took part in training on Monday morning before Chelsea fly to Rome for their latest Champions League Group C contest against AS Roma.
Traore joined Lyon from Chelsea for £8.8m in the summer transfer window but is already thinking about returning to Stamford Bridge.
Chelsea striker Alvaro Morata has admitted he made a mistake by leaving Juventus to rejoin Real Madrid in the summer of 2016.
Belgian missed the first month of the season after undergoing ankle surgery but insists he is now back to his best.
Eden Hazard scores the only goal of the match as Chelsea beat Bournemouth and return to the Premier League's top four.
Antonio Conte has reiterated that the final decision on sales rests with Chelsea after being quizzed on the summer departure of Nathan Ake to Bournemouth.
Antonio Conte has confirmed that N'Golo Kante and Victor Moses will miss the trip to Bournemouth but the Chelsea midfielder could recover in time to face AS Roma.
Rhian Brewster's hat-tricks against USA and Brazil in the quarter-final and semi-final of the 2017 Fifa World Cup in India has helped England book a place in the final.