Los Blancos travel to Barcelona on top La Liga, six points ahead of their arch-enemies.
Los Blancos host Cultural Leonesa on Wednesday before their weekend trip to the Nou Camp.
Having scored three or more goals 39 times with Real Madrid Ronaldo owns Spain's scoring record.
Toni Kroos and Alvaro Morata will also miss the game due to injury.
Ronaldo signed for the Reds as a teenager in 2003.
Ronaldo was widely criticised for his role in Rooney's dismissal.
Mesut Ozil joined Arsenal from Real Madrid in 2013.
Ronaldo signed for the Premier League giants in 2003.
Former Manchester United star wants to continue with Los Blancos until he is 41 years old.
Bale has scored in 49 games in which Real Madrid just registered a single defeat.
Boss believes former Manchester United star should retire at the Bernabeu.
Portugal international agrees to stay at the Santiago Bernabeu until 2021.
Karim Benzema also failed to complete the training with the rest of his teammates.
Ten Premier League players have made the 23-man shortlist.
Antoine Griezmann and Gareth Bale would both be worthier recipients of award.
Ronaldo has previously won the coveted award three times.
Dani Carvajal has been left out of the 19-man squad following his injury scare against in Copa del Rey.
Sergio Ramos, Casemiro and Luka Modric remain on the sidelines.
Zlatan Ibrahimovic, Sergio Aguero, Kevin De Bruyne, Dimitri Payet and Hugo Lloris also on 30-man shortlist.
Toni Kroos last week also committed himself to the La Liga giants until 2022.
The Portuguese signed for United in 2003 amid strong interest from Arsenal.
Rafa Benitez signed the Dutchman from Ajax as a prospect for the future in 2007.