Brazilian duo are also set to miss the Champions League encounter with Borussia Dortmund.
Spaniard played under the City boss at Barcelona before moving to Chelsea.
Duo are back available after missing victory over Espanyol.
Sight of the two stars coming off was seen as a big deal until last season.
Duo missed the 2-0 victory over Espanyol due to illness and injury respectively.
Ronaldo played for Barcelona, Real Madrid, Inter Milan and AC Milan during his career.
Manager Zinedine Zidane is unwilling to take a risk on either player amid throat and hip problems.
Los Blancos travel to Barcelona on Sunday following a 2-1 victory over Sporting Portugal.
Former Barcelona and Real Madrid striker adds that Lionel Messi is the best player in the world.
Former Tottenham star was forced off during 2-1 victory over Sporting.
Portuguese international already returned to action in the weekend victory over Osasuna.
Spaniard may be ready to return to action following a sprained ankle.
Barcelona and Real Madrid stars have been making history for years, but there is more to do.
Alexis Sanchez played a key role in helping Chile win back-to-back Copa America titles.
James Rodriguez, Casemiro and Marcelo will miss the game following their international duties.
The highest-rated midfielders in EA Sports' latest with passing, dribbling and shooting stats.
Portuguese star yet to play since Euro 2016 final against France.
The Portugal captain has been out of action since injuring his knee in the final of Euro 2016.
Ronaldo suffered a knee injury in the Euro 2016 final against France.
Butt claims Manchester United's academy is heading in the right direction.
EA Sports reveals top three players, rounding off its top 50.
Portuguese star yet to play since Euro 2016 final against France.