England's batting collapsed at the beginning of their chase, but Moeen Ali chipped in with a valuable half-century.
The 38-year old paceman is the only active cricketer in the world with 600 Test wickets to his name.
England must win the third Test against Pakistan to reach second place in the ongoing ICC World Test Championship.
The 38-year old will be eager to reach the 600-wicket mark this summer, as he is nine short of the milestone.
Broad, who now has three demerit points, will be suspended if he receives another one.
Anderson is 10 short of 600 Test wickets, but his form and his overall fitness have dipped recently.
The hosts need to build massive partnerships to avoid defeat in the first Test against Pakistan.
Babar Azam was dismissed by James Anderson early on day two without adding anything to his first-day score.
England's 2011 World Cup horror against the Irish brigade has repeated itself in Southampton.
England must continue their winning spree if they want to win the 2021 ICC World Test Championship.
Ireland will need to win more matches in the upcoming weeks to qualify for the 2023 Cricket World Cup.
This is West Indies' seventh consecutive tour in England where they faced Test series defeat.
West Indies needs to score a marathon 399 runs on day five to win their first Test series in England after 32 years.
Broad is one wicket away from becoming the second-ever English bowler to claim 500 Test wickets.after James Anderson.
The West Indies haven't won a Test series in England in the last 32 years.
The 25-year old will have to self-isolate for five days and within that period, he will be tested twice for COVID-19.
Joe Root returns to captaincy following the birth of his second child
Stokes will become the first allrounder since Andrew Flintoff to lead England in a Test match
With a global spike in COVID-19 positive cases, ICC might postpone this year's flagship tournament until February 2021.
Umpires will warn each team twice during an innings for applying saliva on the ball before adding five penalty runs to the opponent's score
The last international cricket game was played between Australia and New Zealand at the Sydney Cricket Ground on March 13
The USA is currently developing six international grade cricket venues to introduce a domestic T20 league