Nick Easter and Jack Nowell both score hat-tricks but Lancaster faces tougher challenges ahead.
Dejected tournament hosts finish their woeful campaign with a Pool A dead rubber at the Etihad Stadium.
Gary Cahill, Joe Hart and James Milner also absent from squad for final Euro 2016 qualifier.
The Arsenal and Manchester City wingers net amid an insipid England showing at Wembley.
Reports from South Africa suggest the former Springbok and Italy coach has been contacted over job.
England face Estonia in the 2016 Euro qualifiers on Friday. Find out how to follow the match live in the UK.
Captain Rooney will also miss the trip to Lithuania next week after injuring his ankle against Arsenal.
The Premier League gians will visit Everton just after the international break.
Danny Ings and Jonjo Shelvey also out after picking up weekend injuries.
26-year-old has ambitions of being England's first choice at left-back for Euro 2016.
Bernard Foley excels as England become the first host nation to fail in their quest to reach the last eight.
Defeat to Wales has left Stuart Lancaster's side needing to win in order to avoid an early exit.
Manchester United face Arsenal in the Premier League on 4 October prior to the international break.
A defeat for hosts England will see them exit the Rugby World Cup at the first round.
Dan Biggar is once against the savour for Warren Gatland but Wales' fate is not yet decided.
Liverpool striker Daniel Sturridge has been omitted by Roy Hodgson despite recovering from hip surgery.
Courtney Lawes is replaced by Joe Launchbury, while Ben Youngs has shaken off an ankle problem.
Former Ireland stalwart does not believe Burgess is anywhere near ready to play international rugby union.
Warren Gatland's side prevail 28-25 to leave hosts needing to beat Australia in seven days time.
Six Nations rivals face off in a crunch Pool A encounter at Twickenham with plenty on the line.
The crunch match between England and Wales is one of the early highlights of this year's tournament.
George North, Jamie Roberts, Alun Wyn Jones and Taulupe Faletau are all recalled by Warren Gatland.