Kick-off: 12:30pm
Chelsea have only one loss since the turn of the year.
Martial last featured in United's draw to Liverpool at Old Trafford on 15 January.
Xhaka is banned for four matches after picking up his second straight red of the season against Burnley.
Jurgen Klopp has resolved not to make widespread changes to his side for fourth round clash at Anfield.
IBTimes UK profiles Wycombe Wanderers' lower-league celebrity ahead of fourth round clash.
Southampton have never beaten Arsenal in the FA Cup in their previous four meetings.
Wolves defeated Stoke City in the third round of the FA Cup.
Argentine winger has spent the last fortnight in Rome as he continues to battle a mystery hip problem.
Manager Dean Smith refused to confirm whether Bees top scorer will start match.
Wolverhampton manager admits Championship is still his side's main focus.
Jan Vertonghen is expected to return within four weeks, while Erik Lamela will be reassessed on Friday.
Welbeck has played just 21 minutes of football in all competitions since his injury return.
Alderweireld suffered a hamstring injury during Tottenham's 2-2 draw against City.
Rojo and Phil Jones have established themselves as Mourinho's first choice centre-back pairing.
Stand-in captain was the hero on Wednesday night as Liverpool edged past Plymouth in a third-round replay.
Lucas Leiva leads the Merseyside club into the fourth round but Klopp was far from content.
League Two high-flyers unable to produce the shock of the round against the seven-time winners.
Reports suggest that Matip will not play any part in Wednesday's third-round replay at Plymouth.
Liverpool and Plymouth settled for a 0-0 draw at Anfield on 8 January.
The National League will have two representatives in the last 32 after a dramatic night.
Harry Wilson could make Reds' debut in third-round tie while Loris Karius will start in goal.