Aspas already made the move to the Premier League when he joined Liverpool from Celta Vigo in 2013.
Los Blancos are now one point behind Barcelona, but still have one game in hand.
Jorge Sampaoli, Ernesto Valverde and Mauricio Pochettino among the contenders.
Enrique, 46, says he needs a 'rest' after three years in charge of the Catalan giants.
Los Blancos want to overtake Manchester United and Barcelona as highest-paid club in world football.
Speaking exclusively to IBTimes UK, Cañizares addressed the goalkeeping dilemma at the Santiago Bernabeu.
Jeremy Mathieu and long-term casualty Aleix Vidal will also miss the game due to injuries.
Catalans host Luis Enrique's hometown side following 2-1 victory over Atletico Madrid.
Former Spurs star had knock in 3-2 win over Villarreal but is available to face Canarians.
Dutch boss said to be on shortlist of candidates to take the reigns at Nou Camp next season.
Real Madrid looking to extend their advantage at the top of the La Liga table.
Barcelona looking to keep the pressure on La Liga leaders Real Madrid.
Versatile defender sprained the external ligaments in his left ankle during 2-1 win over Atletico Madrid.
Wales international was replaced in the 88th minute after picking up a knock.
Real benefited from a contentious penalty decision in their 3-2 win over Villarreal.
Visitors looking to return to winning ways after midweek defeat at Valencia.
Barcelona can go top of La Liga with victory over Atletico at the Vicente Calderon.
Alli is being courted by some of Europe's top clubs.
Los Blancos face Villarreal, Las Palmas and Eibar in the space of seven days.
Spaniard is expected to miss the rest of the 2016-2017 campaign.
28-year-old said to be Catalans' main target to replace Aleix Vidal
Spanish under-21 international is very happy at the Basque side.