Jose Mourinho's side suffered third defeat in a week against at Vicarage Road.
Arsenal and Leicester also ease to victory on a goal-laden Saturday of Premier League football.
Pep Guardiola's side can move five points clear at the top of the table.
Club Brugge and Leicester City face each other in the Champions League clash on 14 September.
Captain suffered strained ligaments in his foot during the 2-2 draw against Swansea.
Arsenal have signed Lucas Perez this season to compensate for their failure to sign Vardy.
Roberto Firmino's brace inspired Reds to convincing win in first home match of the season.
Premier League champions looking for just their second win of the season.
Liverpool and Leicester have won just one of their three games this season.
The Algeria international joined the league champions on transfer deadline day.
French defender Mamadou Sakho has returned to full fitness.
Brazilian midfielder says Anfield must be turned into fortress for Jurgen Klopp's side to be successful.
IBTimes UK lists every top-flight player likely to be called up for the Africa Cup of Nations in Gabon.
Merseysiders host the Foxes before a Friday trip to Chelsea.
Jamie Vardy scored 24 goals for Leicester City last season.
Brazilian midfielder already made the bench against Tottenham Hotspur.
France international played a key role in Leicester City's title triumph last season.
Fuchs's contract talks with Leicester are reported to have run into trouble.
The England international has still to find the net in the Premier League this season.
Holding joined the Gunners from Bolton Wanders for £2m.
Spaniard enjoyed a trophy-laden spell in charge of the Catalans.
Manchester City boss Pep Guardiola is set to return to Barcelona with his new club.