Naomi Osaka will be facing Victoria Azarenka in the women's singles final on Saturday.
The disqualification of Novak Djokovic means the US Open will crown a first-time Grand Slam winner on Sunday.
The world number one apologized for hitting the ball in disgust after losing his serve.
The reigning Australian Open champion Kenin is yet to drop a set at Flushing Meadows as she bids for her second Grand Slam title of the year, and of her career.
The 33-year old Serbian is eager to win his 18th Grand Slam at the Flushing Meadows this year.
The US Open is the first Grand Slam since the Australian Open in January and February.
After numerous players pulled out prior to the event, one player has withdrawn on Sunday due to a positive coronavirus test.
Meanwhile, Spain's Marcel Granollers has replaced France's Benoit Paire in the men's singles draw.
The Serbian world number one is eyeing his 18th Grand Slam title with the US Open starting on August 31.
Both Williams and Murray could only make it into the third round of the event.
The Western and Southern Open is being played in New York this year in preparation for the US Open.
The 33-year old Serbian is currently three short of Federer's 20-Grand Slam tally, and two short of Nadal's 19 major titles.
The world number two is the latest star to join a growing list of players who decided to pull out of the US Open.
The 23-time Grand Slam winner hasn't won a major final since the birth of her daughter in 2017.
The USA continues to be the worst-hit country in the world during the novel coronavirus pandemic.
Williams only made it up to the quarter-finals while Gauff was booted out in the semis.
WTA world number one Ashleigh Barty, fifth-ranked Elina Svitolina, and number seven Kiki Bertens have already pulled out of the 2020 US Open.
Players at the Prague Open are advised to stay isolated and not to shake hands with each other during and after their matches.
Nadal is the latest high profile player to pull out of the Grand Slam event.
Spanish health ministers have recommended the cancellation of the event amid the novel coronavirus pandemic.
There were some 350 fans allowed into a venue that normally holds 1,500.
Kyrgios has always been a critic of returning to competition amid the coronavirus pandemic.