FULL TIME: Manchester United 5-1 FC Midtjylland

Manchester United progress to the last 16 6-3 on aggregate

17-year-old Regan Poole is now on for his United debut. We are almost done here.

Memphis has been utterly sublime this evening and how he has his deserved goal. Starting the move out on the left, he exchanges passes before cutting in and drilling one into the corner from the edge of the box.

Goal! Manchester United 5-1 FC Midtjylland (Memphis Depay, 89)

RED CARD - Rømer

Rømer has been thoroughly tormented by Memphis all night and he's fouled the Dutchman again, earning himself a yellow card.

Rashford is on a hat-trick, but United still have business here so Ander Herrera steps up to take it. He hammers it into the far corner, prompting a million cries and tweets of 'THAT'S HOW YOU TAKE A PENALTY.'

Goal! Manchester United 4-1 FC Midtjylland (Ander Herrera, 87)

Another penalty! Memphis (again) comes in menacingly from the left and curls one that looks for destined for the top corner. Hansen sticks out his hand to block and it is clear penalty and a booking for the defender.

Looks like there will be another cameo appearance for Andreas Pereira this evening, he is about to come on with five minutes remaining.

Around seven minutes of this contest left now. Do United push for the fourth that would settle this? Midtjylland could still notch a late one here and end United's Europa League campaign and overshadow the Marcus Rashford fairytale.

Onuachu rises to meet a free kick and gets his noggin to it, but can't keep it on target. United really need another to rest easy.

Memphis just beat is man with the most audacious piece of skill. Words won't do it justice, I'm afraid.

Memphis just beat is man with the most audacious piece of skill. Words won't do it justice, I'm afraid.

Another goal for Midtjylland would see them progress on away goals still so this isn't over yet. Marcos Rojo meanwhile is on to replace Joe Riley.

Rashford has another! It's brilliant work from Varela down the right, who drags the ball back onto his left foot after reaching the byline, dinking an inviting ball back into the six yard area where the 18-year-old is poised to tuck home his second of the game.

Goal! Manchester United 3-1 FC Midtjylland (Marcus Rashford, 74)

Jesse Lingard is booked for diving following a wild sliding challenge from Romer. United players are furious it isn't a penalty. It did look like one on a first look, but on the replay the United winger looked to have gone down without any contact.

Memphis shows brilliantly trickery inside the box, going inside and out looking for a shot. Initially the ball is nicked off him, but instantly won it back to jink past two more defenders before going for a chipped effort on goal that is blocked.

Rashford was off the pitch at the moment after receiving a bit of treatment and as soon as he was back on, drove towards the Midtjylland goal at pace, eventually playing the ball out to his right.

Sub for the away side meanwhile as Rilwan Hassan goes off and is replaced by Vaclav Kadlec.

Rashford has a debut goal! Schneiderlin's overhit ball is diligently chased down by Mata who cuts an excellent ball back across goal. Rashford peels off his man brilliantly and makes no mistake from six yards out. 3-3 on aggregate.

Goal! Manchester United 2-1 FC Midtjylland (Marcus Rashford, 63)

Midtjylland are taking their sweet time with their free-kicks and have another one when Blind fouls Onuachu. The ball is swung in menacingly but Romero rises to punch clear. The Argentine has had another solid evening so far tonight; not many shots to save but he has been decisive and commanding when coming out to clear the ball.

Memphis again drives down the inside left after United managed to recycle an attack, only to be fended off by Hansen.

We are approaching the hour mark at Old Trafford, Manchester United have had two golden chances to pull level on aggregate in this half, spurned by Ander Herrera and Morgan Schneiderlin.

Romero is called into action, leaping out to claw a cross away right from under Sisto who was looking for his second. Olsson is leading Midtjylland on the counter on each occasion and they look dangerous in doing so.

What a chance for Herrera! Memphis, who has been outstanding tonight, digs out another wonderful cross that the Spaniard reaches with a powerful header, but he can't keep it down and nuts it over the bar.

Rashford neatly turns his man after receiving a pass from Schneiderlin, winning a free kick for his side.

Big chance for Schneiderlin! Mata takes his time and lifts a wonderful ball across goal to find the Frenchman at the far post. He hits it first time, sending it across goal but it is never in any danger of veering in and Novak can clear.

Mata runs to the byline and digs out a cross that wins a corner for his side in these early stages.

And we are back and underway at Old Trafford.

HALF TIME: Manchester United 1-1 FC Midtjylland

Just a minute of time added on to a first half which has flown by.

More brilliance from Memphis as he backheels the ball into the path of Herrera who is clearly tripped as he races into the box. It's a clear penalty, and still on those duties, Mata steps up to take. It side foots towards the left hand corner but Andersen reads it and springs across to make a vital save!

MISSED! (Juan Mata)

PENALTY - Manchester United

There is is something we haven't seen much of this season, Memphis winning the ball back in his own half! The Dutchman robs possession and surges forward again, reaching the penalty area before he he is held up by two defenders.

Memphis whips another devilish cross in that causes havoc as Midtjylland fail to clear. With the ball still bouncing in the air, Schneiderlin comes to meet it with his back to goal and tries his luck with a wonderful overhead kick, missing the far post by inches!

Memphis is having a cracking game. Just inside the left of the box, he weaves past his man and scoops another cross into the six yard area that just evades Mata. The Dutchman is growing in confidence all the time, if United do manage to come out on top tonight - and it's a very big if given they are still behind on aggregate - you feel it will be down to him.

Memphis cross was a good one, Rashford would surely have converted from six yards out had Bodurov not stuck his boot on it.

United have one back! A ball is scooped wide to Memphis on the left who dances past his man with ease. He races down the byline and cuts back an inviting cross that Bodurov sticks a leg out to intercept. The cross has too much pace on it however and he can only ping it past his own goalkeeper.

Goal! Manchester United 1-1 FC Midtjylland (own goal)

Sisto has done it again! Receiving the ball on the edge of the box, he dances past Blind and over a poor challenge from Michael Carrick before arrowing a fine finish into the bottom corner. Outrageously bad defending from the home side.

Goal! Manchester United 0-1 FC Midtjylland (Sisto, 27)

Midtjylland have a moment to enjoy a bit of possession until Morgan Schneiderlin slides in expertly to intercept. It looked a fine tackle to everyone bar the referee it seems, who pulls up for a foul.

Novak dallies on a clearance inside his own box, inviting Jesse Lingard to charge in to close him down. He almost gets lucky, as the clearance clangs off and back on goal, only to bounce the wrong side of the post.

A nice bit of invention from Varela who chips a ball into the box but Rashford misjudges it and the ball bounces off the back of him and Midtjylland can clear.

United are firmly in control as we approach the 20 minute mark. A couple of efforts from range by Memphis and that chance from Rashford have shown the home side can find space tonight; they just need to be a bit more clinical.

Rashford denied! A throw in from the left finds the teenager who darts inside past his man with a neat step over before firing on goal, but his effort is saved by Andersen.

Rashford battles well down the inside right flank, holding off Novak before bursting past the full-back but he overhits his cross into the middle that sails out of play.

Memphis is almost robbed off possession out on the left but manages to squeeze a pass through for Riley, who tries to win a corner for his side, settling for a throw in.

Memphis picks up the ball and dances in from the left past two challenges, looking to find the kind of shot he rifled into the top corner against Club Brugge back in August. He finds the space but this time his effort is charged down.

Here's confirmation by the way of that late injury to Anthony Martial.

18-year-old Marcus Rashford gets us started at Old Trafford and we are underway.

And the players make their way out onto the pitch.

When it rains, it pours. Then it really starts lashing it down and suddenly you are drowning. That's Manchester United's current predicament with Anthony Martial now RULED OUT after an injury in his warm-up. Marcus Rashford will come in for his senior debut.

ANOTHER INJURY!! Well, maybe. Anthony Martial's warm-up has been curtailed slightly, it seems.

A reminder, Manchester United welcome Arsenal to Old Trafford on Sunday. Imagine the damage Arsene Wenger's side could cause against this United XI.

Old man Marcos Rojo is senior player on the United bench tonight at the grand old age of 25. He's surrounded by J.Pereira (19), Poole (17), McNair (20), Love (21), A.Pereira (20) and Rashford (18).

Remember Sisto causing United problems with his direct running and pace a week ago? Now it's Daley Blind and Michael Carrick tasked with dealing with that. While Midtjylland are likely to sit back tonight, you feel United's defensive partnership will need plenty of protection from Morgan Scheiderlin if they are to get through the night unscathed.

A couple of interesting selection changes from Louis van Gaal, who is trying to contend with an obscene amount of injuries. Michael Carrick is preferred to Paddy McNair at centre-half while 18-year-old Joe Riley replaces Cameron Borthwick-Jackson.

Andreas Pereira can't seem to find a way into this team no matter what he does. Despite his bright cameo, he remains on the bench, alongside the returning Marcos Rojo.

Midtjylland team to face Manchester United: Andersen, Rømer, Hansen, Bodurov, Novak, Sparv, Poulsen, Olsson, Hassan, Sisto, Urena

BREAKING: Joe Riley starts at left-back for United this evening but Chris Smalling misses out. Michael Carrick drops in at centre-half to replace him.

Manchester United team to face Midtjylland: S.Romero; Varela, Carrick, Blind, Riley; Schneiderlin, Ander Herrera; Lingard, Mata, Memphis; Martial.

Subs: Subs: Joel Pereira, Rojo, Poole, McNair, Love, Andreas Pereira, Rashford

Joe Riley, who has come off the bench in United's last two games, looks set for a full debut this evening.

It's bizarre to think Cameron Borthwick-Jackson, a 19-year-old who made his senior debut in November last year, has been United's most seasoned full-back option in recent weeks. With Marcos Rojo, Antonio Valencia, Luke Shaw, Ashley Young and Matteo Darmian all sidelined, the likes of Guillermo Varela, Donald Love and most recently Joe Riley have all made their debuts.

18-year-old Marcus Rashford is to be included in the match day squad, possibly for the next few weeks with the club's other forward options currently sidelined.

Here is the Manchester United squad that trained on Wednesday.

Goalkeepers: Sergio Romero, Joel Castro Pereira.

Defenders: Donald Love, Joe Riley, Marcos Rojo, Guillermo Varela, Daley Blind, Regan Poole, Paddy McNair

Midfielders: Morgan Schneiderlin, Ander Herrera, Michael Carrick, Antonio Valencia, Jesse Lingard, Adnan Januzaj, Andreas Pereira, Juan Mata.

Forwards: Marcus Rashford, Memphis Depay, Anthony Martial.

TEAM NEWS: United's injury woes have lumbered from bad to worse in recent weeks. David de Gea is still not available after suffering that knee injury in the warm-up ahead of the first leg. Chris Smalling faces a late fitness test after crashing into an advertising board in the win over Shrewsbury Town, while Cameron Borthwick-Jackson is another doubt.

Louis van Gaal told reporters this week Marcos Rojo will be included in the squad tonight while Antonio Valencia is also nearing his return. It's still pretty bleak out there, however, with Will Keane, Matteo Darmian, Phil Jones, Luke Shaw, Marouane Fellaini, Bastian Schweinsteiger, Ashley Young and Wayne Rooney all still out. Adnan Januzaj meanwhile is ineligible.

Lille 2005. Basel 2011. Olympiakos 2014. FC Midtjylland 2016. Last Thursday's defeat in Denmark was right up there with Manchester United's worst European performances in recent memory. Louis van Gaal's side wilted and, in the end, stopped caring against an opponent who were considered easy pickings when their name came out of the hat last December. A staggeringly bad performance saw the Premier League giants brushed aside with consummate ease in that 2-1 defeat, a result that highlighted the glaring concerns running through this team more harshly than ever.

Only Sergio Romero, the man called into replace David de Gea minutes from kick-off, left Denmark with a positive note to his name. United urgently need to rectify that tonight.

Van Gaal has already indicated United's best hope of qualifying for next season's Champions League now rely on them winning the Europa League. United don't even look favourites to win this tie at the moment, let alone good enough to reach May's final. But in front of an Old Trafford crowd tonight, they are more than capable of rescuing their European campaign. But anything close to resembling the show we saw a week ago will rightfully see them given the boot.