Tottenham are trailing Chelsea by 7 points.
Chelsea cannot afford to drop any more points away from home at this stage of the season.
The 27-year-old has undergone knee scan on issue that forced him to miss midweek draw with Liverpool.
Josh King strikes late to dent Reds' Champions League hopes.
Liverpool lost the revere fixture against Bournemouth 4-3.
Klopp says Liverpool's focus remains on winning the league tie against Eddie Howe's side.
Michail Antonio and Diafra Sakho could return to action in the London derby.
Mane has scored 13 goals this season in the league.
However, Eddie Howe admits that midfielder may well see his future elsewhere.
Mings absence could prove costly for the Cherries.
Duo charged following Manchester United's fiery Premier League clash with Bournemouth on Saturday.
Ibrahimovic, 35, could face retrospective action from the FA after his elbow on Mings.
United were held to a 1-1 draw by 10-man Bournemouth at Old Trafford despite creating numerous chances.
Ibe suffered no ill effects from the knock during training.
Shaw has not started a league game since October.
Wilshere's future at Arsenal is shrouded in uncertainty.
Jesus has scored three goals in four Premier League appearances for City.
Jesus, 19, was substituted 14 minutes into the match against Bournemouth after injuring his ankle.
Bournemouth are currently without a win in six games.
Wilshere is on loan at Bournemouth while Arsenal have a midfield crisis.
Ake spent the first half of the season on loan at Bournemouth before returning to Stamford Bridge.
Begovic is being courted by Bournemouth.