David Ospina has not played for Arsenal since 28 September due to a groin injury and could start against cologne on Thursday.
Michael Zorc will remain at Borussia Dortmund as sporting director and will not follow Sven Mislintat to Arsenal.
The Gunners trail City by 12 points, having already suffered four defeats in their opening 12 fixtures.
Sven Mislintat has joined Arsenal as the head of recruitment after spending 10 years with Borussia Dortmund.
Arsenal fans have been spotted in Zimbabwe holding a 'Wenger Out' sign during protests against Robert Mugabe's presidency.
Tottenham are yet to compete for a major trophy in years, despite finishing 11 points ahead of Arsenal last season.
Mustafi was rated as a doubt by Wenger on Thursday, but the defender was seen training with the first-team on Friday ahead of Arsenal's game against Tottenham.
Spurs travel to the Emirates on Saturday and could go seven points clear of Arsenal with a win in the derby.
Harry Kane and Dele Alli have attracted interest from Real Madrid and Barcelona and could be potential targets for the La Liga giants in the future.
Tottenham are yet to compete for a major trophy in nine years, despite finishing 11 points ahead of Arsenal last season.
Harry Kane picked up a knee injury before the international break and continues to remain a doubt for Spurs' clash against Arsenal.
Sven Mislintat is the latest man to be linked with a move to Arsenal as the club continue to consider candidates to lead their backroom team overhaul.
Former Arsenal and Tottenham midfielder Bentley believes a Gunners' move for Bale would "set the cat amongst the pigeons".
Arsene Wenger insists he does trust striker Alexandre Lacazette despite omitting him from the start in a number of Arsenal's key games this season.
Jack Wilshere is in the final year of his Arsenal contract and is free to discuss a Bosman transfer with foreign clubs from January.
Arsene Wenger denies that his position will be under review at the end of the season, although reiterates that he will sit down with the Arsenal board.
Welbeck has missed the Gunners' last six matches with a hamstring injury but, provided he suffers no complications, is likely to feature against Spurs.
Jan Vertonghen overcame an ankle injury to captain Belgium to victory over Japan on Tuesday, 14 November, and will be available for Spurs' clash against Arsenal.
Ozil, 29, is in the final year of his Arsenal contract, which means he will be free to discuss a Bosman move with foreign clubs from January.
Danny Welbeck will be available for Arsenal's game against Spurs on Saturday (18 November) following his recovery from a hamstring injury.
Gunners boss Arsene Wenger has already started planning for a future without Sanchez, who is in the final year of his contract at the club.
The Frenchman has not started a league game this season and has only been part of the team's Europa League and League Cup campaigns so far.
