Murray's win gave Great Britain an unassailable 3-1 lead over Belgium.
Edmund will hope to bounce back from his thrilling five-set defeat to David Goffin on day one.
The tie's two highest-ranked players do battle in a pivotal singles rubber at Flanders Expo.
Murray brothers beat David Goffin and Steve Darcis in four sets to take a crucial 2-1 lead in the final.
The Murray brothers will hope to hand Great Britain a vital 2-1 lead at Flanders Expo in Ghent.
Tie finely poised at 1-1 heading into Saturday's doubles rubber in Ghent following 6-3, 6-2, 7-5 win.
Edmund took a two-set lead before Goffin's fightback.
Murray is likely to feature in doubles action on Saturday.
Edmund, 20, begins Great Britain's Davis Cup final campaign on 27 November.
Great Britain are aiming to win their first Davis Cup in 79 years.
British number two will have appeal against Davis Cup ineligibility heard by the ITF on Tuesday.
The new world number two reaches semi-finals in French capital but hints at back issues.
Murray eased past the American with a comfortable straight sets win.
The multi-purpose Flanders Expo will hold Belgium's first Davis Cup final appearance for 111 years.
Murray overcomes Tomic 7-5 6-3 6-2 as Britain take unassailable 3-1 lead in Glasgow.
IBTimes UK look ahead to a potential fifth rubber between Great Britain v Australia.
IBTimes UK looks ahead to the fourth rubber of the semi-final between Murray and Tomic.
British pair win 4-6 6-3 6-4 6-7 6-4 in a doubled thriller in Glasgow.
IBTimes UK looks ahead to the second day of action in the Davis Cup semi-final between Great Britain and Australia.
Great Britain drew first blood as Murray thrashed the 19-year-old in straight sets.
Standard Life, one of Murray's sponsors, and ATP to match Murray's donation.
IBTimes UK look ahead to the second round of Great Britain v Australia.