Old Trafford plays host to the first leg as Jose Mourinho's side face The Tigers
The Tigers travel to Old Trafford with a squad hampered by injuries.
Captain handed in transfer request following the summer speculations linking him with Manchester United.
Dawson suffered a shoulder injury in the FA Cup win over Swansea City.
Manager claims it is 'pretty likely' that Loris Karius will start again at St Mary's on Wednesday night.
Manchester United have already defeated Hull City 1-0 in the Premier League this season.
Yaya Sanogo has not been part of a competitive fixture since April.
Mkhitaryan, 27, set up two goals in United's 4-1 win over the Hammers in the EFL Cup.
Arsenal ended their 19 match unbeaten run with loss to Southampton.
Red Devils set up a meeting with Hull City in the EFL Cup semi-finals.
Gunners crashed out of the EFL Cup following a disappointing defeat to the Saints.
Rooney is one short of Sir Bobby Charlton's all-time United record of 249 goals.
United beat West Ham 4-1 in EFL Cup quarter-final on 30 November.
Two-legged semi-finals to take place in January.
Draw for semi-final to take place after tonight's matches.
Striker sustained thigh injury during Sunday's draw with Manchester United.
Paul Pogba and Marouane Fellaini are both suspended after picking up fifth bookings.
Liverpool and Hull City are the first two teams to qualify for the semi-finals of the EFL Cup.
Manchester United and West Ham United face each other in the EFL Cup quarter-final clash at Old Trafford.
Lucas Perez returns to Gunners squad while Carl Jenkinson starts at right-back.
Arsene Wenger has never won the League Cup during his 20 years with Arsenal.
Goals from Divock Origi and Woodburn sealed 2-0 win at Anfield.