The Hammers' move to the stadium has been blighted by crowd trouble.
The Croat will select his playing XI after overseeing their final training session.
De Bruyne was sold by Mourinho during his second spell in charge of the Blues
Danny Ings has made just one appearance for Liverpool so far this season.
Kurt Zouma made his first appearance in over nine months for Chelsea U23 against Derby County.
The last three games between Liverpool and Tottenham have ended in draws.
Marouane Fellaini suffered the injury following a rash tackle by David Luiz.
17-year-old Marcus Edwards is also out due to an ankle injury.
However, the Liverpool boss has no plans to ditch Loris Karius as his number one in the Premier League.
Arsenal and Reading had faced each other in the League Cup in 2012 with the game ending 7-5 in favour of the Gunners.
Ings made his only first-team appearance this season during Liverpool's win over Derby County.
Sissoko elbowed Harry Arter in the final stages of Tottenham's draw against Bournemouth.
Former Villarreal defender was replaced by Marcos Rojo after suffering a suspected knee ligament injury.
Arsene Wenger will consider future of Poland youth international at the end of the year.
Austria international left out squad for draw with Bayer Leverkusen despite Toby Alderweireld injury.
Tottenham will play seven games in 23 days with four of them being away from home.
Erik Lamela and Christian Eriksen were the only regulars to start against Gillingham.
The Spaniard has largely been a peripheral figure under new boss Antonio Conte.
Robins boss Lee Johnson believes the 18-year-old is a "real handful" after netting nine goals in 11 games.
Karius impressed for the Reds in their EFL Cup win against Derby County.
Carrick has not featured for Manchester United in the Premier League this season.
The striker was substituted during Liverpool's 2-1 win against Chelsea at Stamford Bridge.