Mourinho has used a flurry of combinations at the back, with the likes of Eric Bailly, Phil Jones, Chris Smalling and Victor Lindelof all getting into the team at some point.
Anthony Martial comes off the bench to score with nine minutes remaining as Manchester United beat Tottenham 1-0 at Old Trafford.
Zlatan Ibrahimovic said he is close to returning from injury but is not ready to rush his return and risk a setback.
Zlatan Ibrahimovic suffered a knee injury in April and is still on the sidelines. Manchester United signed Romelu Lukaku in summer and the striker has impressed for the Red Devils.
The Swede suffered a serious knee ligament injury in April but could return to action as early as December.
Manchester United were heavily linked with a move for Tottenham's Eric Dier in the summer but Jose Mourinho insists he got the player he always wanted in Nemanja Matic.
IBTimes UK looks at the Tottenham XI Mauricio Pochettino could pick to face Manchester United following the news that Harry Kane will miss out through injury.
Antonio Conte has confirmed that N'Golo Kante and Victor Moses will miss the trip to Bournemouth but the Chelsea midfielder could recover in time to face AS Roma.
Phil Jones and Eric Bailly are in contention to return from injury when Manchester United host Tottenham Hotspur on Saturday.
Spurs have been in brilliant form this season and sit level on points with Jose Mourinho's men following their 4-1 thrashing of Liverpool last gameweek.
Pochettino accused United of "destabilising" Dier with a recent approach but holds no grudge against Mourinho, who he will come up against at Old Trafford on Saturday.
Lamela has not played for Spurs for a year due to hip problems but Pochettino thinks the Argentine is "so close" to a return.
Barcelona have begun conversations with Antoine Griezmann's entourage ahead of making a move to lure him to the Nou Camp during the summer transfer window.
Tottenham have confirmed Harry Kane is carrying a slight hamstring injury ahead of their visit to Manchester United.
Harry Kane, who scored a brace in Tottenham's 4-1 win over Liverpool, was seen leaving the field clutching his hamstring in the 88th minute at Wembley.
Shaw has played just 48 minutes of first-team football for Manchester United this season despite returning to full fitness in September.
Jose Mourinho saw his side suffer a 2-1 defeat against Huddersfield Town in the last league tie. The Portuguese tactician wants his Manchester United players to bounce back against Tottenham.
Manchester United, Arsenal and Bayern Munich have approached Jose Arnaiz's agent to sound out his contract situation at Barcelona.
Manchester United foursome Eric Bailly, Phil Jones, Ander Herrera and Marcus Rashford all took part in training before Saturday's clash with Tottenham.
Anderlecht midfielder Leander Dendoncker says he would already be a Manchester United player if the club had made a more firm bid to sign him last summer.
Carabao Cup quarter-final draw eventually has to be pre-recorded after a technical delay lasting almost two hours.
Luke Shaw's Manchester United career is in jeopardy after a complete breakdown in communication with manager Jose Mourinho.
