Kane missed Tottenham's loss to Manchester United with a minor hamstring injury but Pochettino is hopeful that he will return for their clash against Real Madrid.
Anthony Martial came off the bench and scored the winner in Manchester United's 1-0 victory over Tottenham Hotspur at Old Trafford on 28 October.
Anthony Martial's introduction for Marcus Rashford in the 70th minute was booed by some sections of the Old Trafford support.
Mourinho claims critics 'talk too much' and should 'relax more' after his side beat Spurs 1-0 at Old Trafford.
Anthony Martial comes off the bench to score with nine minutes remaining as Manchester United beat Tottenham 1-0 at Old Trafford.
Dele Alli has emerged as a key player under Mauricio Pochettino at Tottenham Hotspur. His form has seen him attract interest from top clubs across Europe.
Zlatan Ibrahimovic said he is close to returning from injury but is not ready to rush his return and risk a setback.
Kane experienced a number of largely unsuccessful loans in the lower reaches of English football before bursting onto the scene at Spurs.
IBTimes UK looks at the Tottenham XI Mauricio Pochettino could pick to face Manchester United following the news that Harry Kane will miss out through injury.
Barcelona have told Arda Turan, Aleix Vidal and Thomas Vermaelen that they can leave the club during the January transfer window.
Spurs have been in brilliant form this season and sit level on points with Jose Mourinho's men following their 4-1 thrashing of Liverpool last gameweek.
Pochettino accused United of "destabilising" Dier with a recent approach but holds no grudge against Mourinho, who he will come up against at Old Trafford on Saturday.
Lamela has not played for Spurs for a year due to hip problems but Pochettino thinks the Argentine is "so close" to a return.
Harry Kane, who scored a brace in Tottenham's 4-1 win over Liverpool, was seen leaving the field clutching his hamstring in the 88th minute at Wembley.
Shaw has played just 48 minutes of first-team football for Manchester United this season despite returning to full fitness in September.
Manchester United foursome Eric Bailly, Phil Jones, Ander Herrera and Marcus Rashford all took part in training before Saturday's clash with Tottenham.
Redknapp blasts Spurs for being too arrogant and complacent as they let a two-goal slip against West Ham.
Liverpool will be without the services of forward Sadio Mane, midfielder Adam Lallana, full-back Nathaniel Clyne and backup goalkeeper Adam Bogdan.
Tottenham have been in brilliant form this season and sit level on points with United following their 4-1 thrashing of Liverpool last gameweek.
Harry Kane has been in fine form for Tottenham, scoring 13 goals in 12 appearances in all competitions. His absence will be a massive blow for Spurs against Manchester United.
Andre Ayew nets a second-half brace and Angelo Ogbonna heads home the winner as West Ham recover from two goals down to beat Tottenham 3-2 in the Carabao Cup.
Mauricio Pochettino claims that Daniel Levy does not impose age restrictions on incoming Tottenham transfers, with 32-year-old Fernando Llorente adapting well.
