Harry Kane will not be rested despite playing eight times already this season.
Mousa Dembele, Victor Wanyama, Dele Alli and Christian Eriksen all ruled out of Champions League meeting.
Spurs are second in the Champions League Group H following their opening win over Borussia Dortmund.
Kane has scored a total of 105 goals in 172 games in all competitions for Spurs.
Dembele was not named in the squad for Spurs' win over West Ham on Saturday (23 September).
Antonio had to be substituted midway through the first-half.
Serge Aurier sent off for two bookable offences as spirited Hammers just fall short in quest for a point.
Spurs boss dismisses comments made by Tim Sherwood that a move to Barcelona or Real Madrid is imminent.
The left-back has missed the last two games against Swansea and Barnsley.
Chelsea take on Everton, Arsenal meet Norwich and Manchester City host Wolves.
Crystal Palace failed with a late swoop for Turkish international on transfer deadline day.
Hammers boss made 10 changes for Carabao Cup win over Bolton – but could retain that team this weekend.
Liverpool were eliminated from the Carabao Cup following their 2-0 defeat to Leicester City.
Mauricio Pochettino's search for a major trophy at Spurs continues in the EFL Cup.
25 fire engines raced to the scene of the major fire at a warehouse in north London.
Reports suggested that England midfielder had entered discussions over a new deal worth £100,000-a-week.
Mauricio Pochettino believes academy graduate needs to improve confidence and condition after lost season.
Birmingham have already lost 6 games this season.
Spurs' search of their first league win at Wembley continues.
Meunier was linked with a move to Chelsea and Tottenham in the summer transfer window.
Belgium international has two years to run on current deal and could be available for £25m in 2019.
Spurs midfielder split from his agent last month and is looking for a new representative
