Brazilian was ruled out for around five weeks after suffering ankle injury against Sunderland.
Wirrall-based official has not taken charge of a match involving either Everton or Liverpool for 10 years.
February's two-legged last-32 tie against Saint-Etienne will pit Paul Pogba against older brother Florentin.
The German midfielder is a doubt for Wednesday but should be back to face Everton.
Manchester United boss does not want an ankle injury to halt the Armenian's recent evolution.
Gunners boss is hopeful of retaining Alex Oxlade-Chamberlain amid speculation over his future.
Arsene Wenger confident Shkodran Mustafi will only miss three weeks with hamstring injury.
Brazilian has missed last two wins due to suspension.
The other 22 first-team players available train in Japan ahead of the Thursday's semi-final.
Real Madrid and Portugal's Cristiano Ronaldo is one of the firm favourites to win the award this year.
Paul Pogba will face elder brother Florentin in United's first meeting with ASSE since 1977.
Barcelona, Bayern Munich and Real Madrid potentially lie in wait for the Premier League trio.
Dembele was replaced in the 67th minute in Tottenham's 1-0 defeat to Manchester United.
Manchester United and Tottenham are in the draw for the round of 32.
Karius failed to deal with a saveable Dimitri Payet free kick in Liverpool's 2-2 draw with West Ham.
Shkodran Mustafi was substituted in the first half against Stoke.
Arsenal, Manchester City and Leicester City have made it to the knock out stages of the Champions League.
Mkhitaryan scored the winner in Manchester United's 1-0 win over Tottenham Hotspur
Karius has kept three clean sheets in 10 Premier League games for Liverpool.
Guardiola wants to lower the average age of his full-backs at Manchester City.
Blues have being charged over player behaviour five times in the last 19 months.
Spanish pair combine for the winner as the Blues return to the top of the Premier League.
Crewe Alexandra's director of football suspended by the FA amid historic abuse case.
The Reds look to close the gap to Chelsea and Arsenal against the Hammers at Anfield.
Jose Mourinho's side claim first home league win since September against Spurs.
Arsenal have scored 12 goals in their last three games.
Antonio Conte's side go back to the top of the Premier League.
Sergio Ramos scored a dramatic late winner to give Real a 3-2 win over Depor.
Arsenal are top of the league on goal difference at this point.
The Red Devils are currently sixth in the table, 13 points behind leaders Arsenal.