Fabian Delph, Andros Townsend and Marcus Rashford all included in Roy Hodgson's 26-man provisional squad.
Theo Walcott's hopes of making the England squad for Euro 2016 took a further hit after the forward picked up a hamstring injury.
The IBTimes UK sports team select their squad for the summer finals in France.
Costa will play no part against the champions, but Thibaut Courtois is expected to return after illness.
The Eagles could be without two key players for their much-anticipated clash against Manchester United.
The 29-year-old Leicester City forward has enjoyed a record-breaking season with the Foxes.
Three Lions boss set to name his provisional squad next week after an initial injury delay.
Hatem Ben Arfa has been omitted from the 23-man squad despite having a stellar season for Nice in Ligue 1.
The 23-year-old Swiss star is said to be a target for Gunners boss Arsene Wenger this summer.
Roy Hodgson has been monitoring Wilshere's injury all season.
The 30-year-old Bordeaux loanee suffered the problem during Wednesday's 1-1 draw against Paris Saint-Germain.
Welbeck has been on the sidelines after suffering cartilage damage during Arsenal's 2-2 draw with Manchester City.
IBTimes UK sports editor Nick Howson has his say on the England squad for Euro 2016.
The 23-year-old star has enjoyed impressive season in Portugal, attracting the Red Devils' interest.
The Crystal Palace and Wales midfielder suffered the blow during the win over Stoke City.
The Three Lions have a number of injury issues that still need to be resolved before the tournament begins.
Welbeck returned from a 10-month injury layoff in February and is facing yet another spell on the sidelines.
The 25-year-old midfielder is back training and hopes to be fit for Europa League final in Basel.
Real Madrid star currently has a knee injury but is expected to be fit to face Atletico in Milan on 28 May.
Arsene Wenger fears the Gunners striker damaged his lateral meniscus during a lively encounter at the Etihad.
The 18-year-old has impressed United fans since stepping up to the first team this season.
The 22-year-old midfielder will be out of action for six to eight weeks with the problem.