Aleix Vidal and third keeper Jordi Masip return to squad.
De Bruyne scored two goals and registered four assists in six league games for Manchester City.
Live coverage of the 3pm kick-offs in the Premier League including Spurs' trip to the north east.
Manchester City are unbeaten in their last eight games against Swansea.
Spaniard played under the City boss at Barcelona before moving to Chelsea.
Dimitri Seluk believes money and talent led to Pep Guardiola's success over the years.
Teenager is also reported to have attracted interest from Barcelona and Manchester United.
The German made the comments in response to a study led by the CIES Football Observatory.
Spaniard would snub Manchester City as he wants to renew his current deal which is set to expire in 2018.
Manchester United will host Manchester City in the fourth round of the EFL Cup.
Catalans announced agreement with the Spain international in May.
The Brazilian starlet was heavily linked with both Manchester United and Barcelona.
Spanish boss knows defender from his time at Barcelona.
Dimitri Seluk claims he will apologise if Guardiola says sorry to Manuel Pellegrini and Joe Hart.
Manchester City will be looking to extend their unbeaten run when they face Swansea City on Wednesday.
German worked with Klopp earlier in his career at Borussia Dortmund.
Manager incensed with comments made by Toure's agent after Champions League omission.
Atkinson fears Mourinho could create a 'claustrophobic' environment at United.
The Spaniard says City can continue to improve after 4-0 thrashing of AFC Bournemouth.
Arsenal and Leicester also ease to victory on a goal-laden Saturday of Premier League football.
Pep Guardiola's side can move five points clear at the top of the table.
Kompany has missed the entirety of the pre-season with a thigh injury.