All three main indexes in New York suffered hefty selling.
US officials have called on states to prepare to distribute a possible vaccine by November 1.
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The mood in Asia was more downbeat compared with earlier in the week.
The tech sector has been a consistent bright spot amid the severe coronavirus downturn in the United States.
Buying was also boosted by news that Trump had expanded the use of a coronavirus treatment using plasma from people who had recovered from the disease.
The head of the World Health Organization's European branch said new widespread lockdowns would not be needed.
Uncertainty over the stimulus, rising US infections and the Fed's massive bond-buying has hurt the dollar.
Frustrated investors wait for Democrats and Republicans to hammer out a much-needed financial support package.
Analysts said there was little reaction to news that trade review talks between the superpowers due to have taken place Saturday had been postponed.
There was also some cheer about Joe Biden's choice of Kamala Harris as his running mate for November's election.
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Analysts said easing concerns about the future of the China-US trade pact and healthy China data also provided some cheer to investors.
The rapid spread of the disease around the world and fresh flare-ups have caused renewed lockdowns.
With key unemployment benefits, ban on evictions already lapsed for millions, Republicans and Democrats far apart in talks on a fresh economic rescue package.
A spike in coronavirus infections has forced fresh lockdowns and sparked worries about the impact on the world economy.
With the disease showing no sign of easing globally -- total cases topped 18 million Monday -- governments are moving to reimpose containment measures.
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Economists suggested the weak data could spur US lawmakers to push on with fresh stimulus measures as their previous package comes to an end soon.
Reports said Mitch McConnell would soon unveil a $1 trillion plan after overcoming some differences with the White House.
With one eye on developments on Capitol Hill, Asian equities were moving in and out of positive territory.
The studies provided a much-needed shot in the arm for investors, who have been put on edge in recent weeks by worrying spikes in new infections.
An index of US consumer sentiment last week showed it hit a three-month low in July.
Nervousness continues to permeate trading floors as infections spike around the world.
A worrying increase in new cases across the planet has forced governments to revert to measures aimed at preventing the disease's spread.
Investors welcomed German biotech firm BioNTech's comments about a vaccine candidate would be ready for regulatory review by the end of the year.
Asia tracked the New York losses, with profit-taking also playing a part after a broadly strong week.
The easing of lockdowns and a healthy run of economic data have provided a boost to world markets in recent weeks.
Analysts warned that while the employment data were good, jobless claims were still elevated.
Hong Kong led the gains on reopening after a one-day break, despite concerns about a new security law imposed on the city by China.