Pablo Zabaleta still struggling with foot injury with Bacary Sagna also still out.
De Bruyne was sold by Mourinho during his second spell in charge of the Blues
The Spaniard was a second-half substitute against his former club.
Luis Enrique has given a break to some of his key players following victory over Valencia.
Former Villarreal defender was replaced by Marcos Rojo after suffering a suspected knee ligament injury.
Manchester City have not won a match in their last three games played in all competitions.
Pique and Alba are out after being forced off during the win over Manchester City.
The ex-Manchester United captain does not believe Spurs can lift the domestic crown.
Spain internationals limped off in the first half of Barcelona's 4-0 win over Manchester City.
Pep Guardiola's Manchester City is without a win in their last four matches.
Lionel Messi and Mesut Ozil both notch hat-tricks during goal-laden night of European football.
Catalan giants looking to make it 3 wins out of 3 in Champions League Group C.
Kevin De Bruyne, Raheem Sterling, Sergi Aguero and captain Vincent Kompay lead the 21-man squad.
Spanish playmaker spoke to IBTimes UK after his side's 3-2 victory over Swansea City.
Spanish playmaker spoke to IBTimes UK after his side's 3-2 victory over Swansea City.
Spanish duo missed the 4-0 win over Deportivo la Coruna due to injury.
Tottenham maintain unbeaten run but settle for point at West Brom.
Bob Bradley narrowly defeated in first game in charge of the Swans.
Manchester City host Everton in the Premier League.
Vincent Kompany, Fabian Delph, Raheem Sterling and Sergio Aguero may also be available.
German said that he never considered anything other than staying at Spanish giants.
Bild reports that the new deal worth £108m across six seasons.