Chelsea are four points ahead of Tottenham Hotspur.
Nadal will look to win his second clay event in the space of a week.
Tottenham can ensure they finish above Arsenal for the first time since 1995 with a win on Sunday (30 April).
Manchester United face Swansea City in the Premier League clash on Sunday.
Manchester City will finish third in the Premier League if they win their remaining five games.
Rafael Nadal is the defending champion of the Barcelona Open.
Andy Murray will face Dominic Thiem in the 2017 Barcelona Open on Saturday.
Barcelona cannot afford to slip up against city rivals at Cornella-El Prat.
Real Madrid can return to the summit of the La Liga table with a victory over Valencia.
City host United in the Premier League clash on Thursday.
Crystal Palace have won their last two London derbies against Chelsea and Arsenal.
Leicester have never beaten Arsenal in 20 attempts.
Barcelona can go three points ahead of Real Madrid with victory over Osasuna.
FA Cup finalists Chelsea will take on the visiting Southampton on Tuesday (25 April) at Stamford Bridge.
Crystal Palace have won five of their last seven games.
Nadal is looking to make history and win in Monte-Carlo for the 10th time.
Burnley host Manchester United in the Premier League clash on Sunday.
Chelsea and Tottenham are battling for the Premier League title this season.
Monaco have won the first away leg 3-2.
Manchester United host Anderlecht in the Europa League quarter-final clash on Thursday.
Arsenal have lost four away games on the trot for the first time under Wenger.
Liverpool face a tough task against overachievers West Bromwich Albion.